Study: Increasing Consumption of Plant-Based Foods May Mitigate Obesity-Induced Inflammation

New research published in the journal Frontiers in Nutrition has found that increasing the consumption of plant-based foods “may mitigate obesity-induced inflammation and its consequences.”

“Evidence investigating associations between dietary and nutrient patterns and inflammatory biomarkers is inconsistent and scarce”, states the study, which was conducted by researchers at the University of Adelaide, Flinders University and the Cancer Council Victoria, all located in Australia. “Therefore, we aimed to determine the association of dietary and nutrient patterns with inflammation.”

Overall, 1,792 participants from the North-West Adelaide Health Study were included in this cross-sectional study. Researchers “derived dietary and nutrient patterns from food frequency questionnaire data using principal component analysis.” Multivariable ordinal logistic regression determined the association between dietary and nutrient patterns and the grade of inflammation (normal, moderate, and severe) based on C-reactive protein (CRP) values, and “Subgroup analyses were stratified by gender, obesity and metabolic health status.”

The study found that “In the fully adjusted model, a plant-sourced nutrient pattern (NP) was strongly associated with a lower grade of inflammation in men, obesity and metabolically unhealthy obesity”. A mixed NP “was positively associated with higher grade of inflammation in all participants.”

A prudent dietary pattern was inversely associated with a lower grade of inflammation. In contrast, “a western dietary pattern and animal-sourced NP were associated with a higher grade of inflammation in the all participants although BMI attenuated the magnitude of association in the fully adjusted model.”

Researchers conclude by stating that a plant-sourced NP “was independently associated with lower inflammation. The association was stronger in men, and those classified as obese and metabolically unhealthy obese. Increasing consumption of plant-based foods may mitigate obesity-induced inflammation and its consequences.”

More information on this study can be found by clicking here. The abstract can be found below.

Abstract

Purpose: Evidence investigating associations between dietary and nutrient patterns and inflammatory biomarkers is inconsistent and scarce. Therefore, we aimed to determine the association of dietary and nutrient patterns with inflammation.

Methods: Overall, 1,792 participants from the North-West Adelaide Health Study were included in this cross-sectional study. We derived dietary and nutrient patterns from food frequency questionnaire data using principal component analysis. Multivariable ordinal logistic regression determined the association between dietary and nutrient patterns and the grade of inflammation (normal, moderate, and severe) based on C-reactive protein (CRP) values. Subgroup analyses were stratified by gender, obesity and metabolic health status.

Results: In the fully adjusted model, a plant-sourced nutrient pattern (NP) was strongly associated with a lower grade of inflammation in men (ORQ5vsQ1 = 0.59, 95% CI: 0.38-0.93, p-trend = 0.08), obesity (ORQ5vsQ1 = 0.43; 95% CI: 0.24-0.77, p-trend = 0.03) and metabolically unhealthy obesity (ORQ5vsQ1 = 0.24; 95% CI: 0.11-0.52, p-trend = 0.01). A mixed NP was positively associated with higher grade of inflammation (ORQ5vsQ1 = 1.35; 95% CI: 0.99-1.84, p-trend = 0.03) in all participants. A prudent dietary pattern was inversely associated with a lower grade of inflammation (ORQ5vsQ1 = 0.72, 95% CI: 0.52-1.01, p-trend = 0.14). In contrast, a western dietary pattern and animal-sourced NP were associated with a higher grade of inflammation in the all participants although BMI attenuated the magnitude of association (ORQ5vsQ1 = 0.83, 95% CI: 0.55-1.25; and ORQ5vsQ1 = 0.94, 95% CI: 0.63-1.39, respectively) in the fully adjusted model.

Conclusion: A plant-sourced NP was independently associated with lower inflammation. The association was stronger in men, and those classified as obese and metabolically unhealthy obese. Increasing consumption of plant-based foods may mitigate obesity-induced inflammation and its consequences.